Description

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Tags: Evolution, Autism, Lang:en

Summary

Since Epigenetics is one of the most rapidly expanding fields in biology, an attempt has been made in this booklet to include, a comprehensive understanding of epigenetic mechanisms, their interactions and alterations in health and disease, which has become a priority in biomedical research.
The recent characterization of a human DNA methylome at single nucleotide resolution, the discovery of the CpG island shores, the finding of new histone variants and modifications, and the unveiling of genome-wide nucleosome positioning maps highlight the accelerating speed of discovery over the past two years.
Increasing interest in epigenetics has been accompanied by technological breakthroughs that now make it possible to undertake large-scale epigenomic studies in obesity, cancer, autism, aging, endocrine disruptors etc..
These allow the mapping of epigenetic marks, such as DNA methylation, histone modifications and nucleosome positioning, which are critical for regulating gene and noncoding RNA expression.
In turn, we are learning how aberrant placement of these epigenetic marks and mutations in the epigenetic machinery is involved in disease.
.....Dr.H.K.Saboowala.

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